2020 marks the 40th anniversary of the JHI and the Healthcare Infection Society. Our first issue of this anniversary year includes a special section on Gram-negative bacteria. Bulabula et al. report in a systematic review a pooled proportion of MDRGNB transmission from colonized mothers to their infants of 27%; this is useful information when planning infection prevention precautions and making antibiotic prescribing choices on neonatal units. General prevalence data, such as in the study by Henderson et al., who found a CPO prevalence of 3.1% in East London, helps by providing denominator data against which the risk of transmission in different hospital settings can be assessed. Concerning the focus on preventing Gram-negative bloodstream infections, it will be interesting to see responses to the systematic review by Fasugba et al. in which the authors concluded that there is a lack of lack of good-quality trial data to support the hypothesis that increased fluid intake prevents urinary tract infections. Aside from Gram-negative bacteria, the January issue includes a review of prion disease and recommended procedures for flexible endoscope reprocessing, and new International Society of Cardiovascular Infectious Diseases Guidelines for the Diagnosis, Treatment and Prevention of Disseminated Mycobacterium chimaera Infection Following Cardiac Surgery with Cardiopulmonary Bypass. Finally, in the depths of the northern hemisphere winter, Didier Pittet reminds us that alcohol-based handrubs are extremely effective against influenza viruses.